Drug-induced testicular toxicity
نویسندگان
چکیده
منابع مشابه
Dexrazoxane exacerbates doxorubicin-induced testicular toxicity.
Infertility induced by anti-cancer treatments pose a major concern for cancer survivors. Doxorubicin (DXR) has been previously shown to exert toxic effects on the testicular germinal epithelium. Based upon the cardioprotective traits of dexrazoxane (DEX), we studied its potential effect in reducing DXR-induced testicular toxicity. Male mice were injected with 5 mg/kg DXR, 100 mg/kg DEX, combi...
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OBJECTIVE To investigate a possible protective role of lycopene on adriamycin (ADR)-induced spermiotoxicity using quantitative, biochemical and histopathological approaches. DESIGN Experimental study. SETTING Firat University Medical School, Experimental Research Centre, Elazig, Turkey. ANIMALS Twenty four Sprague Dawley rats (8-weeks old) INTERVENTION(S) Adriamycin (10 mg kg(-1)) was i...
متن کاملArsenic induced toxicity on testicular tissue of mice.
Effect of arsenic was studied on the testicular tissue of Swiss albino mice. Sodium-meta-arsenite (NaAsO2) was administered to adult mice (25 +/- 30 g) at a dose level of 30 mg/L and 40 mg/L through drinking water for 30, 45 and 60 days. After the treatment, the testicular organ was removed, weighed and processed for histopathological observation. No change in the body weight was recorded in tr...
متن کاملDITOP: drug-induced toxicity related protein database
MOTIVATION Drug-induced toxicity related proteins (DITRPs) are proteins that mediate adverse drug reactions (ADRs) or toxicities through their binding to drugs or reactive metabolites. Collection of these proteins facilitates better understanding of the molecular mechanisms of drug-induced toxicity and the rational drug discovery. Drug-induced toxicity related protein database (DITOP) is such a...
متن کاملPhytoremedial effect of Withania somnifera against arsenic-induced testicular toxicity in Charles Foster rats
Objective: The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology. Materials and Methods: In the present study, arsenic in the form of sodium arsenite was administered orally ...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2009
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.133.82